Taking painkillers during early pregnancy increases risk of miscarriage

　　According to the United States“ healthy "Japan" reported on September 6 that a new study published in the "Journal of the Canadian Medical Association" published that day found that taking ibuprofen and other non-steroidal anti-inflammatory painkillers (NSAIDs) in early pregnancy will greatly increase the risk of miscarriage.

　　New study leader, Professor of Pharmacy, Université de Montréal, Saint-Justine Hospital Dr. Annick Berard of the Institute of Drugs and Pregnancy said that studies have found that taking NSAIDs painkillers in early pregnancy will increase the risk of spontaneous abortion by an average of 2.4 times.

　　Dr. Berard said that the new study only looked at the effects of NSAIDs prescribed by doctors on pregnancy, but judging from the research, it can be concluded that over-the-counter NSAIDs also increase the risk of miscarriage.

　　Rheumatoid arthritis, lupus, migraine, etc. disease Treatment usually involves NSAIDs. These drugs can provide pain relief in patients who do not have underlying chronic conditions. This drug is commonly used by both general and pregnant patients. Doctors have stopped using these anti-inflammatory painkillers in late pregnancy after studies found they interfere with fetus Normal development of the circulatory system.

　　The new study, completed by Dr. Berard and colleagues, looks at the adverse effects of NSAIDs used during the first 20 weeks of pregnancy. The study involved data from nearly 5,000 women in Quebec who had had a miscarriage and 5,000 women who had not had a miscarriage. The results found that taking NSAIDs in early pregnancy will increase the risk of miscarriage by 2.43 times.

　　The specific circumstances in which NSAIDs drugs increase the risk of miscarriage are: diclofenac increases the risk of miscarriage by 3 times, naproxen (Aleve) increases the risk of miscarriage by 2.64 times, and ibuprofen doubles the risk of miscarriage. Mixed use of multiple drugs can increase the risk of miscarriage by 2.64 times.

　　The specific mechanism by which NSAIDs increase the risk of miscarriage is not fully understood. But researchers believe that such drugs could theoretically interfere with the changes in prostaglandin levels that lead to miscarriage. Dr. Berard said pregnant women occasionally use acetaminophen (acetaminophen) to relieve pain such as headaches, which is relatively safe in early pregnancy.